Moreover, infiltrative glioma cells are known to invade macroscopically unaffected brain regions by occult migration along white matter (WM) bundles 10, 11, and microstructural WM alterations have been reported in diffuse glioma even in the normal-appearing WM, distant to the primary lesion site 12, 13, 14.ĭiffusion-weighted imaging (dMRI) provides estimates of macroanatomic WM tracts, as well as measures for microstructural characterization of WM properties in vivo. cognitive or affective) impairment in these patients, it is understood that by tumor-induced disruptions of cortico-cortical connections, not only perilesional brain regions, but distant brain areas can be functionally affected as well 7, 8, 9. While tumor lesions may not obviously correlate with the functional (e.g. whole-brain, impact of chronically progressive brain lesions such as in glioma patients seems increasingly relevant 3, 4, 5, 6, 7. With the increasing awareness of a network-based rather than traditional localizationist understanding of the organization of cerebral functions 1, 2, determining the systemic, i.e. Connectomic profiling may aid in phenotyping and monitoring prognostically differing tumor types. Findings suggest a relative dissociation of structural and functional connectomic coherence in glioma patients at the time of diagnosis, with more structural connectomic aberrations being encountered in IDHwt glioma patients. Patients however showed a loss in structural and reductions in functional connectomic coherence, which appeared to be more pronounced in IDHwt glioma patients. Healthy controls showed strong intramodal connectivity, each within the structural and functional connectome. With interhemispheric EW being reduced in both patient groups, IDHwt patients showed FA decreases in the ipsi- and contralesional hemisphere, whereas IDHmut patients revealed FA increases in the contralesional hemisphere. SC and FC were determined for whole-brain and the Default-Mode Network (DMN), mean intra- and interhemispheric SC and FC were compared across groups, and partial correlations were analyzed intra- and intermodally. We investigated resting-state functional connectivity (FC) and diffusion-MRI-based structural connectivity (SC) (comprising edge-weight (EW) and fractional anisotropy (FA)) in isodehydrogenase mutated (IDHmut) and wildtype (IDHwt) patients and healthy controls. With diffuse infiltrative glioma being increasingly recognized as a systemic brain disorder, the macroscopically apparent tumor lesion is suggested to impact on cerebral functional and structural integrity beyond the apparent lesion site.
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